Some times menus need to have a mouseover event fired before clicking. Try the following to see if that might help.
Browser(''myBrswer'').Page(''myPage'').Link(''Main Menu'').FireEvent ''onmouseover''
Browser(''myBrswer'').Page(''myPage'').Link(''Main Menu'').Click

Browser(''myBrswer'').Page(''myPage'').Frame(''topmenu'').Link(''Home'').FireEvent ''onmouseover''
Browser(''myBrswer'').Page(''myPage'').Frame(''topmenu'').Link(''Home'').Click
Browser(''myBrswer'').Page(''myPage'').Frame(''leftmenu'').Link(''Personal Lines'').FireEvent ''onmouseover''
Browser(''myBrswer'').Page(''myPage'').Frame(''leftmenu'').Link(''Personal Lines'').Click
Browser(''myBrswer'').Page(''myPage'').Frame(''leftmenu'').Link(''Quote'').FireEvent ''onmouseover''
Browser(''myBrswer'').Page(''myPage'').Frame(''leftmenu'').Link(''Quote'').Click
Browser(''myBrswer'').Page(''myPage'').Frame(''detail'').Link(''Auto'').FireEvent ''onmouseover''
Browser(''myBrswer'').Page(''myPage'').Frame(''detail'').Link(''Auto'').Click

For more information on [Unified Functional Testing
Object Model Reference](https://admhelp.microfocus.com/uft/en/latest/UFT_Help/Content/Landing_Pages/OMR_Overview_Landing_Page.htm) and on [FireEvent Method](https://admhelp.microfocus.com/uft/en/latest/UFT_Help/Subsystems/FunctionReference/Subsystems/OMRHelp/OMRHelp.htm#Web/WEBPACKAGELib~Link.html#FireEvent). Note above links are for UFT 14.01 but should work on most version of UFT.