In the newer versions of Excel, it appears that sometimes the Add-in is being reported under the Com Add-ins and it is necessary to select the Com Add-ins under the manage box in the lower left of the Add-ins page accessed through the Options menu and then within the Com Add-ins box that appears to select the HP Application Lifecycle Management add-in and apply that setting. Then restart Excel to test that it is working at start up as it should (it is listed as load at star-up in the add-in options description).
I have seen in the past where the Add-in gets unloaded/deslected occassioanally after the initial install, and performing these actions resolves the issue.
I have also seen where (and this may be the case here) the user is on a remote system and the way the system is managed (by administrator choice), when the user logs out at the end of the session, the defaults are rolled back to and insome cases the add-in is unloaded (and sometimes uninstalled) for the next logged in session, in this case even though it is still installed it was necessary to re-enable it through the options menu.
Hope this helps others as well,