Hi HomerJ,
Unfortunately no the Safari browser will not work as you are trying to use it. The desktop cliient (which is the full featured client), requires Active X components which Microsoft will only license to itself, so IE browsers in a Windows environment are the only allowed environments for the desktop client (the ALM explorer can also be used but once again it also requires a Windows environment to run).
Now if you enable the webclient (needs to be enabled on a project by project basis in the customization for the project as well as the site admin needs it enabled), this will allow other browsers such as FireFox, Safari, Opera, and Chrome to function with ALM, but each browser has limited functionality and those capabilities change with each new patch and version level released. Eventually the plan is that everything will go to HTML5 standard making the web client as fully functioned as the desktop client but right now that is not the case (and when this happenes it will require a version upgrade as the capability will not be backward capable with current versions). The only allowed modules for non-IE broswers at this time is Requirements, Test case and lab in some browsers, and defects (not all have all modules available). Each has different functionality and HP has not released a document as to what browsers have which functionality (and as stated before each patch and version changes what is available so it is a constant evolving design).
If this is for use within an Apple environment and full desktop client functuonality is needed ( Ia m assuming the as Safari was the mentioned browser), I would suggest either running a VM option (such as parallells, VMWARE, or VirtualBox, WINE, or other VM solution) hosting a windows environemnt on the users system, set up a bootcamp partition and natively run a Windows environment (kind of defeats the purpose of having a Mac though), define a virtual environment to host the applications such as Citrix, or setting up a remote windows client system that users can log into and utilize the full desktop client capabilities. At this time those are the only options available to Non-windows users to utilize the full desktop client and its capabilities.
Hope this helps,
Dan