The architectures provided by virtualization vendors are rapidly evolving. LoadRunner is expected to function as designed in these changing environments, as long as the third-party vendor guarantees full compatibility of the virtualized environment with the LoadRunner-approved hardware requirements.
If you follow the LoadRunner system requirements and support matrix to create the virtual machine, LoadRunner will work correctly.
Working on top of a virtual machine may require access to the virtualization server hardware/monitoring environment to ensure the virtualization server is not saturated; otherwise, this might obscure the virtual machine's measurements and lead to false results.